The preparation and resolution of 2-(2-pyridyl)-and 2-(2-pyrazinyl)-Quinazolinap and their application in palladium-catalysed allylic substitution

SP Flanagan, R Goddard, PJ Guiry

Index: Flanagan, Susan P.; Goddard, Richard; Guiry, Patrick J. Tetrahedron, 2005 , vol. 61, # 41 p. 9808 - 9821

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Citation Number: 40

Abstract

The preparation and resolution of two new axially chiral quinazoline-containing phosphinamine ligands, 2-(2-pyridyl)-Quinazolinap and 2-(2-pyrazinyl)-Quinazolinap, is described. The ligands were synthesised in good yield over eight steps and included two Pd- catalysed reactions, a Suzuki coupling to form the biaryl linkage and the introduction of the diphenylphosphino group, as the key transformations. The racemic ligands were resolved ...