Tetrahydroisoquinoline based sulfonamide hydroxamates as potent matrix metalloproteinase inhibitors

D Ma, W Wu, G Yang, J Li, J Li, Q Ye

Index: Ma, Dawei; Wu, Wengen; Yang, Guoxin; Li, Jingya; Li, Jia; Ye, Qizhuang Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 1 p. 47 - 50

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Citation Number: 23

Abstract

The synthesis and MMP inhibitory activity of a series of tetrahydroisoquinoline based sulfonamide hydroxamates are described. In nine MMPs tested, most of the compounds display potent inhibition activity except for MMP-7. Some subtle isozyme selectivity is observed by varying the substituents at the 6-and 7-positions and aromatic ring of arylsulfonyl groups.