Biodegradable cross-linked poly (amino alcohol esters) based on LMW PEI for gene delivery

S Li, Y Wang, J Zhang, WH Yang, ZH Dai, W Zhu…

Index: Li, Shuo; Wang, Yu; Zhang, Ji; Yang, Wei-Han; Dai, Zhen-Hua; Zhu, Wen; Yu, Xiao-Qi Molecular BioSystems, 2011 , vol. 7, # 4 p. 1254 - 1262

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Citation Number: 19

Abstract

Polyethylenimine (PEI, especially with Mw of 25000) has been known as an efficient gene carrier and a gold standard of gene transfection due to its high transfection efficiency (TE). However, high concomitant cytotoxicity limited the application of PEI. In this report, several cationic polymers derived from low molecular weight (LMW) PEI (Mw 600) linked with diglycidyl adipate (DA–PEI) or its analogs (diglycidyl succinate, DS–PEI and diglycidyl ...