Thiazolothiazoles. II. Parent heterocycle and its carboxylic and amino derivatives

JR Johnson, DH Rotenberg…

Index: Johnson,J.R. et al. Journal of the American Chemical Society, 1970 , vol. 92, # 13 p. 4046 - 4050

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Citation Number: 41

Abstract

Abstract: Side chain oxidation of 2, 5-bis-@-styryl and 2, 5-bis-2-furylthiazolo [5, 4-d] thiazole with permanganate furnished 2, 5-thiazolothiazoledicarboxylic acid in good yields. The dicarboxylic acid has served as starting material for a variety of thiazolothiazole derivatives that are inaccessible by direct routes. Stepwise decarboxylation led to 2- thiazolothiazolecarboxylic acid and to the parent heterocycle. Thiazolothiazole is ...