Chemistry Letters

A convenient synthesis of 5-aryltropolones via novel benzidine type rearrangement of 2-(2-arylhydrazino) tropones

T Nozoe, K Takase, H Saito, H Yamamoto, K Imafuku

Index: Nozoe, Tetsuo; Takase, Kahei; Saito, Hiroaki; Yamamoto, Hiroshi; Imafuku, Kimiaki Chemistry Letters, 1986 , p. 1577 - 1580

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Citation Number: 8

Abstract

Treatment of a wide variety of 2-(2-arylhydrazino) tropones with ethanolic acid at 50–80° C readily gave the benzidine type rearrangement products, ie 2-amino-5-(4-aminoaryl) tropones, which in turn were conveniently led to the corresponding 5-aryltropolones that can be utilized for synthesizing B-ring-open analogues of colchicine.

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Synthesis and Reactions of 2-Arylhydrazinotropones. II. Synthesis of 5-Aryltropolones and B-Ring-Open Colchicine Analogues via Benzidine Type Rearrangement of …

[Nozoe, Tetsuo; Takase, Kahei; Yasunami, Masafumi; Ando, Masayoshi; Saito, Hiroaki; et al. Bulletin of the Chemical Society of Japan, 1989 , vol. 62, # 1 p. 128 - 142]

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