Synthesis and evaluation of antiproliferative activity of a novel series of hydroxychavicol analogs

…, EA Owens, V Sharma, R Aneja, M Henary

Index: Yadav, Yogesh; Owens, Eric A.; Sharma, Vibhuti; Aneja, Ritu; Henary, Maged European Journal of Medicinal Chemistry, 2014 , vol. 75, p. 1 - 10

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Citation Number: 3

Abstract

Abstract We have recently demonstrated that hydroxychavicol is a major constituent and the most active biophenolic of Piper betel leaves with significant antiproliferative activity in the micro molar range. Herein we present the design, synthesis and evaluation of fifteen novel hydroxychavicol analogs with varying antiproliferative activities in cancer cell lines from two representative tissue types, namely, the prostate and cervix that show very encouraging ...