Organocatalyzed Asymmetric Synthesis of Dihydrodibenzofurans Based on a Dienamine Process
ZY Wang, WT Wong, D Yang
Index: Wang, Zi-Yu; Wong, Wing-Tak; Yang, Dan Organic Letters, 2013 , vol. 15, # 19 p. 4980 - 4983
Full Text: HTML
Citation Number: 11
Abstract
The first organocatalyzed asymmetric method for the synthesis of dihydrodibenzofurans based on a dienamine process has been developed. This two-step protocol works with a broad range of substrates and delivers only the cis-diastereomer in good yield with up to 91% ee. The enantioenriched products have been transformed to highly functionalized and partially hydrogenated dibenzofurans in excellent diastereoselectivities.
Related Articles:
Retinoide-II: Darstellung von 13-methoxyretinal
[Natsias, Konstantin; Hopf, Henning Tetrahedron Letters, 1982 , vol. 23, # 36 p. 3673 - 3676]