Practical synthesis of PC190723, an inhibitor of the bacterial cell division protein FtsZ

NA Sorto, MM Olmstead, JT Shaw

Index: Sorto, Nohemy A.; Olmstead, Marilyn M.; Shaw, Jared T. Journal of Organic Chemistry, 2010 , vol. 75, # 22 p. 7946 - 7949

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Citation Number: 17

Abstract

The emergence of pathogenic bacteria that are resistant to current antibiotics requires the exploration of new methods for treating infections caused by these organisms. Recent efforts have included finding new ways to modify the structures of existing antibiotics as well as discovering and developing new leads and new molecular targets. One promising area of development involves inhibiting bacterial cell division.(1) The central protein required for bacterial cytokinesis is FtsZ, a ...