Strikingly simple direct α-allylation of aldehydes with allyl alcohols: remarkable advance in the Tsuji-Trost reaction

…, Y Horino, R Mukai, S Tanaka, Y Tamaru

Index: Kimura; Horino; Mukai; Tanaka; Tamaru Journal of the American Chemical Society, 2001 , vol. 123, # 42 p. 10401 - 10402

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Citation Number: 115

Abstract

Palladium-catalyzed allylic alkylation of active methylene compounds such as β-ketoesters and malonates (the Tsuji-Trost reaction) is a reliable and widely used method for CC bond formation. 1 However, the R-allylic alkylation of nonstabilized ketones and aldehydes remains to be developed. The alkylation reported so far requires both reaction partners to be preactivated: allyl alcohols as their esters and halides and ketones and aldehydes as their ...