1-Substituted 7-[3-[(ethylamino) methyl]-1-pyrrolidinyl]-6, 8-difluoro-1, 4-dihydro-4-oxo-3-quinolinecarboxylic acids. New quantitative structure activity relationships at …

…, CL Heifetz, MP Hutt, TF Mich, JB Nichols…

Index: Domagala, John M.; Heifetz, Carl L.; Hutt, Marland P.; Mich, Thomas F.; Nichols, Jeffry B.; et al. Journal of Medicinal Chemistry, 1988 , vol. 31, # 5 p. 991 - 1001

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Citation Number: 114

Abstract

A series of 18 1-substituted 743-[(ethy1amino) methyll-1-pyrrolidinyl]-6, 8-difluoro-1, 4- dihydro-4-oxo-3-quinoline-carboxylic acids (Nl analogues of CI-934) were synthesized and evaluated for antibacterial activity and DNA-gyrase inhibition. Correlations between the inhibition of DNA gyrase and antibacterial potency were established. A quantitative structure- activity relationship (QSAR) was derived by using the antibacterial potency for each of 11 ...

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[Sanchez, Joseph P.; Domagala, John M.; Hagen, Susan E.; Heifetz, Carl L.; Hutt, Marland P.; et al. Journal of Medicinal Chemistry, 1988 , vol. 31, p. 983 - 991]

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