One-pot reductive amination of aldehydes and ketones with α-picoline-borane in methanol, in water, and in neat conditions
S Sato, T Sakamoto, E Miyazawa, Y Kikugawa
Index: Sato, Shinya; Sakamoto, Takeshi; Miyazawa, Etsuko; Kikugawa, Yasuo Tetrahedron, 2004 , vol. 60, # 36 p. 7899 - 7906
Full Text: HTML
Citation Number: 178
Abstract
A one-pot reductive amination of aldehydes and ketones with amines using α-picoline- borane as a reducing agent is described. The reaction has been carried out in MeOH, in H2O, and in neat conditions in the presence of small amounts of AcOH. This is a highly efficient and mild procedure that is applicable for a wide variety of substrates. In particular, this is the first successful demonstration that this type of reaction can be carried out in ...
Related Articles:
[Liu, Bo; Roisnel, Thierry; Carpentier, Jean-Francois; Sarazin, Yann Angewandte Chemie - International Edition, 2012 , vol. 51, # 20 p. 4943 - 4946]
Alkylaminomethylation d'organomagnesiens
[Yankep, Emmanuel; Kapnang, Henriette; Charles, Georges Tetrahedron Letters, 1989 , vol. 30, # 52 p. 7383 - 7384]