Structure-activity studies on anticonvulsant sugar sulfamates related to topiramate. Enhanced potency with cyclic sulfate derivatives

BE Maryanoff, MJ Costanzo, SO Nortey…

Index: Bourne,E.J. et al. Journal of the Chemical Society, 1965 , p. 3798 - 3802

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Citation Number: 119

Abstract

... Journal of Medicinal ... of several analogues of 2 (83a−r, 85−87, 90a, 91a, 93a) indicated that potent anticonvulsant activity is associated with relatively small alkyl substituents on nitrogen (Me/H, 83a; Me/Me, 83m; Et/H, 83b ... figure. Table 1. Chemical Properties and Biological Data. ...