D2 Dopaminergic and 5??HT1A Serotonergic Activity of 2??(1??Naphthyl) ethyl??and 2??(2??Naphthyl) ethyl Amines

V Šukalović, G Roglić, S Husinec…

Index: Sukalovic; Roglic; Husinec; Kostic-Rajacic; Andric; Soskic, Vukic Archiv der Pharmazie, 2003 , vol. 336, # 11 p. 514 - 522

Full Text: HTML

Citation Number: 3

Abstract

Abstract Several tertiary 2-phenylethyl, 2-(1-naphthyl) ethyl and 2-(2-naphthyl) ethyl amines were synthesized and their binding affinities for dopamine D 1, D 2 and serotonin 5-HT 1A receptors evaluated in radioligand binding assays. All compounds were inactive in D 1 dopamine radioligand binding assay. The 2-(1-naphthyl) ethyl analogues expressed a low but significant binding affinity for the D 2 and moderate one for the 5-HT 1A receptor ...