Synthesis and pharmacological evaluation of N-substituted 4, 6-diaryl-3-pyridazinones as Analgesic, antiinflammatory and antipyretic agents.

…, P COUDERT, P TRONCHE, J BASTIDE…

Index: Rubat; Coudert; Tronche; Bastide; Privat Chemical and Pharmaceutical Bulletin, 1989 , vol. 37, # 10 p. 2832 - 2835

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Citation Number: 31

Abstract

The synthesis and the pharmacological evaluation of 19 new 4, 6-diaryl-3-pyridazinones are reported. All compounds were screened for analgesic, antiinflammatory and antipyretic activities. Introduction of an arylpiperazinomethyl moiety in the 2-position of the pyridazinone ring resulted in the most potent activities. Compounds 2a, 2b, 2h and 2i exhibited a higher analgesic activity than did aspirin or noramidopyrine in the hot plate test.