The Journal of Organic Chemistry

A Convenient Synthesis of N, N'-Disubstituted Formamidines and Acetamidines1

EC Taylor, WA Ehrhart

Index: Taylor,E.C.; Ehrhart,W.A. Journal of Organic Chemistry, 1963 , vol. 28, p. 1108 - 1112

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Citation Number: 94

Abstract

The reaction of ethyl orthoformate with alkylamines in the presence of acetic acid has been shown to lead to N, N'-dialkylformamidines in good yield. Under similar conditions ethyl orthoacetate gives N, iV'-dialkylacetamidines. Reaction of ethyl orthoacetate with one mole of an aromatic amine, preferably in the presence of acetic acid, gives an ethyl A'- arylacetimidate, while reaction with two moles of an aromatic amine in the presence of ...