A copper-and amine-free Sonogashira reaction employing aminophosphines as ligands

J Cheng, Y Sun, F Wang, M Guo, JH Xu…

Index: Cheng, Jiang; Sun, Yanhui; Wang, Feng; Guo, Minjie; Xu, Jian-Hua; Pan, Yi; Zhang, Zhaoguo Journal of Organic Chemistry, 2004 , vol. 69, # 16 p. 5428 - 5432

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Citation Number: 177

Abstract

An efficient Pd-catalyzed Sonogashira coupling reaction was achieved in the absence of a copper salt or amine with an inorganic base and easily prepared, air-stable aminophosphine ligands in commonly used organic solvents; good to excellent yields were obtained. Under optimized reaction conditions, the Sonogashira coupling reaction occurred selectively when an enyne substrate was employed and no Heck reaction product was ...