A simple and efficient method for the preparation of hindered alkyl-aryl ethers

TF Woiwode, C Rose, TJ Wandless

Index: Woiwode, Thomas F.; Rose, Christoph; Wandless, Thomas J. Journal of Organic Chemistry, 1998 , vol. 63, # 25 p. 9594 - 9596

Full Text: HTML

Citation Number: 51

Abstract

Antimitotic natural products that bind to cellular microtubules can be used as anticancer agents, and we are studying the cellular mechanisms of these compounds. 1 The fungal metabolite phomopsin A is a key structure in these studies, and we are currently pursuing its synthesis. 2 Our retrosynthetic analysis of phomopsin A targeted the chiral tertiary alkylraryl ether as a key disconnection within the molecule. Accordingly, we have investigated ...