Iron (III)??Catalyzed Addition of Benzylic Alcohols to Aryl Alkynes–A New Synthesis of Substituted Aryl Ketones

U Jana, S Biswas, S Maiti

Index: Jana, Umasish; Biswas, Srijit; Maiti, Sukhendu European Journal of Organic Chemistry, 2008 , # 34 p. 5798 - 5804

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Citation Number: 35

Abstract

Abstract A new, efficient and direct addition of benzylic alcohols with terminal aryl alkynes was developed with the inexpensive, non-toxic, FeCl 3 catalyst in nitromethane. The reaction provides a simple method for the synthesis of substituted aryl ketones under mild conditions, and the reaction is highly atom-economical. Several substituted terminal alkynes underwent smooth reaction with various substituted benzylic alcohols. The electron-rich ...