Chemical Communications

Copper-catalyzed coupling reaction of unactivated secondary alkyl iodides with alkyl Grignard reagents in the presence of 1, 3-butadiene as an effective additive

R Shen, T Iwasaki, J Terao, N Kambe

Index: Shen, Ruwei; Iwasaki, Takanori; Terao, Jun; Kambe, Nobuaki Chemical Communications, 2012 , vol. 48, # 74 p. 9313 - 9315

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Citation Number: 24

Abstract

We previously reported on the development of efficient catalytic systems for cross-coupling reactions of alkyl halides with Grignard or organozinc reagents using Ni, Pd as well as Cu catalysts in the presence of π-carbon ligands, such as 1,3-butadiene, 11c tetraenes 11e or an alkyne. 12d These reactions proceed efficiently for a variety of primary alkyl halides, even alkyl chlorides and fluorides, 12 providing a convenient tool for the construction of carbon–carbon bonds. ...