Tetrahedron letters

The first total synthesis and neurotrophic activity of clusiparalicoline A, a prenylated and geranylated biaryl from Clusia paralicola

S Takaoka, K Nakade, Y Fukuyama

Index: Takaoka, Shigeki; Nakade, Kousuke; Fukuyama, Yoshiyasu Tetrahedron Letters, 2002 , vol. 43, # 39 p. 6919 - 6923

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Citation Number: 29

Abstract

The first synthesis of clusiparalicoline A, a prenylated and geranylated biphenyl compound isolated from the roots of Clusia paralicola, has been achieved by applying the sequential palladium-catalyzed Stille and Suzuki reactions to the formation of all the C C bonds on electron-rich aryl bromide and triflate. Clusiparalicoline A has been found to exhibit a potent neurite outgrowth promoting activity at 1.0 μM in a primary culture of fetal rat cortical ...