Synthesis of 2-boryl-and silylindoles by copper-catalyzed borylative and silylative cyclization of 2-alkenylaryl isocyanides

…, H Fujihara, K Koh, N Chatani

Index: Tobisu, Mamoru; Fujihara, Hirokazu; Koh, Keika; Chatani, Naoto Journal of Organic Chemistry, 2010 , vol. 75, # 14 p. 4841 - 4847

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Citation Number: 67

Abstract

We have developed a method for the synthesis of 2-borylindoles via the copper (I)-catalyzed borylative cyclization of 2-alkenylphenyl isocyanides using diboronate. The reaction proceeds at room temperature under neutral conditions and exhibits high tolerance to functional groups, such as Br, CO2R, COR, CONMe2, and CN. The 2-borylindoles synthesized in the present study can be elaborated into an array of indole-based ...

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