Il Farmaco

Synthesis and cytotoxic effect of carbocyclic potential minor groove binders

…, T Anchim, M Dąbrowska, K Midura-Nowaczek

Index: Bartulewicz, Danuta; Anchim, Tomasz; Dabrowska, Milena; Midura-Nowaczek, Krystyna Farmaco, 2004 , vol. 59, # 3 p. 211 - 214

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Citation Number: 5

Abstract

New carbocyclic potential minor groove binders were synthesised, using 3-nitrobenzoyl chloride and aliphatic α, ω-diamines with three, four and five methylene fragments. The half structures, compounds IV–VI can be compared to bis-amidines, compounds X–XII to bis- netropsin. All of the compounds were investigated antiproliferative and cytotoxic effects in the standard cell line of mammalian tumour MCF-7.