Russian chemical bulletin

Regioselective phosphorylation of α-N-alkylamino ketones

…, YV Balitsky, NV Simurova, AD Sinitsa

Index: Pipko; Balitsky; Simurova; Sinitsa Russian Chemical Bulletin, 2006 , vol. 55, # 2 p. 295 - 300

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Abstract

Abstract General preparative methods for regioselective functionalization of α-amino ketones with organophosphorus reagents were developed. Stable phosphorylated derivatives of all their prototropic forms (α-amino ketones, α-hydroxy imines, and β-hydroxy enamines) were obtained for the first time. The relative thermodynamic stability sequence of α-amino ketones was found to be reversed upon their phosphorylation: O-substituted ...