Synthesis

Asymmetric Direct Michael Addition of Acetophenone to α, β-Unsaturated Aldehydes

W Li, W Wu, J Yang, X Liang, J Ye

Index: Li, Wenjun; Wu, Wenbin; Yang, Juanjuan; Liang, Xinmiao; Ye, Jinxing Synthesis, 2011 , # 7 p. 1085 - 1091

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Abstract

Abstract The asymmetric direct Michael addition of α, β-unsaturated aldehydes with acetophenone catalyzed by a Jørgensen-Hayashi catalyst in methanol was developed and the corresponding Michael products of δ-keto aldehydes could be afforded in up to 82% yield and 98% ee.