The Journal of Organic Chemistry

Convenient method for the titration of amide base solutions

RE Ireland, RS Meissner

Index: Ireland, Robert E.; Meissner, Robert S. Journal of Organic Chemistry, 1991 , vol. 56, # 14 p. 4566 - 4568

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Citation Number: 28

Abstract

3 4 inherent instability of the bases in solution, the titer of these commercial products often varies widely as a result of storage. In addition, direct preparations of some of these amide bases from the appropriate metal hydride and amine are heterogeneous reactions and as such are often not quantitative. 2 In many reactions, the precise knowledge of a base solution's titer is required in order to exploit properly the selectivity and characteristics of a ...