The design of efficient and selective routes to pyridyl analogues of 3-oxo-3, 4-dihydro-2H-1, 4-(benzothiazine or benzoxazine)-6-carbaldehydes

…, DT Davies, AJ Hennessy, GE Jones, RE Markwell…

Index: Brooks, Gerald; Dabbs, Steven; Davies, David T.; Hennessy, Alan J.; Jones, Graham E.; Markwell, Roger E.; Miles, Timothy J.; Owston, Nathan A.; Pearson, Neil D.; Peng, Tony W. Tetrahedron Letters, 2010 , vol. 51, # 38 p. 5035 - 5037

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Citation Number: 11

Abstract

This Letter describes the synthesis of challenging pyridyl analogues of 3-oxo-3, 4-dihydro- 2H-1, 4-(benzothiazine or benzoxazine)-6-carbaldehydes. The six different routes described are high yielding, contain no major purification issues and have been used to give gram quantities of each aldehyde.