XH-14 analogues as adenosine antagonists

PJ Scammells, SP Baker, AR Beauglehole

Index: Scammells, Peter J.; Baker, Stephen P.; Beauglehole, Anthony R. Bioorganic and Medicinal Chemistry, 1998 , vol. 6, # 9 p. 1517 - 1524

Full Text: HTML

Citation Number: 27

Abstract

Analogues of the potent adenosine antagonist 5-(3′-hydroxypropyl)-7-methoxy-2-(3′- methoxy-4′-hydroxyphenyl) benzo [b] furan-3-carbaldehyde (XH-14, 1) with alternate substituents in the 2-, 5-and 7-positions have been synthesised. The affinity of these compounds for the A1 adenosine receptor has been evaluated using a [3H] CPX competitive binding assay. This structure-activity study highlighted the importance of the 3-formyl and ...