A convenient laboratory procedure for the preparation of cortalcerone, a fungal antibiotic β-pyrone

J Gabriel, J Volc, E Kubátová, Z Palková…

Index: Gabriel; Volc; Kubatova; Palkova; Pospisek Carbohydrate Research, 1994 , vol. 252, p. 297 - 301

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Citation Number: 14

Abstract

The unsaturated P-pyrone antibiotic'cortalcerone (2-hydroxy-6H-3-pyrone-2- carboxaldehyde hydrate, 1) was first prepared from aqueous macerates of mycelia from the basidiomycete Corticium caeruleum, by selective solubilization and precip itation followed by repeated silica-gel column chromatography. Subsequent studies2T3 showed that cortalcerone is derived from o-glucose through a multi-step pathway involving oxidation of ...