Synthetic Communications

Annulation Reactions of Ortho-Chloromethyl Aryl Cuprates

CR Nevill Jr, PL Fuchs

Index: Nevill, C.R.; Fuchs, P.L. Synthetic Communications, 1990 , vol. 20, # 5 p. 761 - 772

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Citation Number: 7

Abstract

Abstract Formation of o-chloromethyl aryl cuprates via halogen-metal exchange of 2- iodobenzyl chlorides with n-butyllithium provides a cuprate that may be added to unhindered enones and ammonium salt 5 giving intermediates suitable for subsequent annulation reactions.