Efficient synthesis of 8, 11-dimethylene-bicyclo [5.3. 1] undecan-2-one
H Gu, WM Xu, TH Kinstle
Index: Gu, Haining; Xu, Wei Ming; Kinstle, Thomas H. Tetrahedron Letters, 2005 , vol. 46, # 38 p. 6449 - 6451
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Citation Number: 8
Abstract
The bicyclo[5.3.1]undecane ring system is a substructure of naturally occurring taxanes. Among them, the most prominent representative compound is taxol, 1 a clinically useful anti-cancer drug. Due to its therapeutic potential and its limited availability, enormous efforts have been directed towards the chemical synthesis of taxol in the past decade. 2 The construction of the AB-ring core of taxol, which involves the bicyclo[5.3.1]undecane moiety, is among the most ...
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