The Journal of Organic Chemistry

The acyl effect on intramolecular palladium-catalyzed trimethylenemethane cycloadditions

BM Trost, TA Grese

Index: Trost, Barry M.; Grese, Timothy A. Journal of Organic Chemistry, 1992 , vol. 57, # 2 p. 686 - 697

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Citation Number: 36

Abstract

Enhancing the generality of the intramolecular palladium-catalyzed [3+ 21 cycloaddition involving tri-methylenemethane complexes as reactive intermediates is possible by incorporation of acyl substituents on the TMM unit. Such substituted TMM-PdL2 species greatly expand the scope such that bicyclo [3.3. 0] octyl, bicyclo [4.3. 0] nonyl, and bicyclo [5.3. 0] decyl ring systems all can be created. Furthermore, the acyl-TMM chemistry ...