Trifluoromethylation of Aromatic Isoxazoles: Regio??and Diastereoselective Route to 5??Trifluoromethyl??2??isoxazolines

H Kawai, K Tachi, E Tokunaga, M Shiro…

Index: Kawai, Hiroyuki; Tachi, Kentaro; Tokunaga, Etsuko; Shiro, Motoo; Shibata, Norio Angewandte Chemie - International Edition, 2011 , vol. 50, # 34 p. 7803 - 7806

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Citation Number: 43

Abstract

5-Trifluoromethyl-2-isoxazolines with a quaternary carbon center bearing a CF3 group are part of an important class of heterocyclic compounds with remarkable biological activities, which make them promising synthetic targets in the fields of medicinal chemistry and agrochemistry.[1] Particularly since the discovery of the structurally unique 3, 5-diaryl-5- (trifluoromethyl)-2-isoxazoline derivatives A (Scheme 1; R1= R4=