Synthesis and cannabinoid receptor activity of ketoalkenes from Echinacea pallida and nonnatural analogues

…, P Pellett, K Nickl, S Geiger, S Graetz…

Index: Egger, Michael; Pellett, Patrina; Nickl, Kathrin; Geiger, Sarah; Graetz, Stephanie; Seifert, Roland; Heilmann, Joerg; Koenig, Burkhard Chemistry - A European Journal, 2008 , vol. 14, # 35 p. 10978 - 10984

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Citation Number: 12

Abstract

Abstract Despite its popularity and widespread use, the efficacy of Echinacea products remains unclear and controversial. Among the various compounds isolated from Echinacea, ketoalkenes and ketoalkenynes exclusively found in the pale purple coneflower (E. pallida) are major components of the extracts. In contrast to E. purpurea alkamides, these compounds have not been synthesized and studied for immunostimulatory effects. We ...