Tetrahedron letters

Synthesis of 2-dimethylaminoimidazole derivatives: a new access to indolyl-imidazole alkaloids of marine origin.

A Dalkafouki, J Ardisson, N Kunesch, L Lacombe…

Index: Dalkafouki, Angeliki; Ardisson, Janick; Kunesch, Nicole; Lacombe, Liliane; Poisson, Jacques E. Tetrahedron Letters, 1991 , vol. 32, # 39 p. 5325 - 5328

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Citation Number: 18

Abstract

Abstract The first preparation of 2-dimethylaminoimidazole 1a, a structural feature of several marine products was undertaken and its reactivity investigated. The synthesis of natural alkaloids5 and 12b was achieved by direct coupling of the easily accessible oxidized 2- dimethylaminoimidazoles 7 and 8 with indole-3-carboxaldehyde and indole respectively, demonstrating the usefulness of this approach for other structurally related natural ...