Cooperative Organocatalysis for the Asymmetric γ Alkylation of α??Branched Enals

…, S Vera, P Melchiorre

Index: Bergonzini, Giulia; Vera, Silvia; Melchiorre, Paolo Angewandte Chemie - International Edition, 2010 , vol. 49, # 50 p. 9685 - 9688

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Citation Number: 148

Abstract

The direct, catalytic, and stereoselective functionalization of carbonyl compounds at the g position represents a highly challenging and persistent problem for asymmetric synthesis.[1, 2] All attempts to solve this problem must address the challenge of site selectivity as well as stereoselectivity.[3] Recently, our research group hypothesized whether dienamine catalysis could provide a general platform for designing direct vinylogous processes,[4] by ...