Synthesis and pharmacology of 11-nor-1-methoxy-9-hydroxyhexahydrocannabinols and 11-nor-1-deoxy-9-hydroxyhexahydrocannabinols: new selective ligands for …

KSC Marriott, JW Huffman, JL Wiley…

Index: Marriott, Karla-Sue C.; Huffman, John W.; Wiley, Jenny L.; Martin, Billy R. Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 7 p. 2386 - 2397

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Citation Number: 21

Abstract

Fourteen novel CB2 receptor selective cannabinoids were synthesized via initial Lewis acid catalyzed rearrangement of resorcinol precursors to obtain the cannabinoid moiety. These are the 1-methoxy-9-hydroxyhexahydrocannabinols and the 1-deoxy-9- hydroxyhexahydrocannabinols, with 1′, 1′-dimethylalkyl side chains of four to seven carbon atoms at C-3 of the cannabinoid nucleus. The cannabinols synthesized and ...