Influence of Na+ on DNA reactions with aromatic epoxides and diol epoxides: evidence that DNA catalyzes the formation of benzo [a] pyrene and benz [a] anthracene …

H Fernando, CR Huang, A Milliman, L Shu…

Index: Fernando, Harshica; Huang, Chao-Ran; Milliman, Ann; Shu, Luchuan; LeBreton, Pierre R. Chemical Research in Toxicology, 1996 , vol. 9, # 8 p. 1391 - 1402

Full Text: HTML

Citation Number: 7

Abstract

Reactions of the benzo [a] pyrene (BP) and benz [a] anthracene (BA) metabolites,(±)-trans-7, 8-dihydroxy-anti-9, 10-epoxy-7, 8, 9, 10-tetrahydro-BP (BPDE),(±)-trans-3, 4-dihydroxy-anti- 1, 2-epoxy-1, 2, 3, 4-tetrahydro-BA (BADE),(±)-BP-4, 5-oxide (BPO), and (±)-BA-5, 6-oxide (BAO), were examined under pseudo-first-order conditions at varying Na+ (2.0-100 mM) and native, calf thymus DNA (ctDNA) concentrations. In 0.2 mM ctDNA and 2.0 mM Na+, at a ...

Related Articles:

Absolute configurations of K-region epoxide enantiomers of 3-methylcholanthrene, benz [a] anthracene, and benzo [a] pyrene

[Weems, Henri B.; Mushtaq, Mohammad; Yang, Shen K. Analytical Chemistry, 1987 , vol. 59, # 22 p. 2679 - 2688]

Absolute configurations of K-region epoxide enantiomers of 3-methylcholanthrene, benz [a] anthracene, and benzo [a] pyrene

[Weems, Henri B.; Mushtaq, Mohammad; Yang, Shen K. Analytical Chemistry, 1987 , vol. 59, # 22 p. 2679 - 2688]

Acid-catalyzed rearrangement of K-region arene oxides: observation of ketone intermediates and a sterically induced change in rate-determining step

[Nashed, Nashaat T.; Sayer, Jane M.; Jerina, Donald M. Journal of the American Chemical Society, 1993 , vol. 115, # 5 p. 1723 - 1730]

Solvolysis of K-region arene oxides: substituent effects on reactions of benz [a] anthracene 5, 6-oxide

[Nashed, Nashaat T.; Balani, Suresh K.; Loncharich, Richard J.; Sayer, Jane M.; Shipley, David Y.; Mohan, Ram S.; Whalen, Dale L.; Jerina, Donald M. Journal of the American Chemical Society, 1991 , vol. 113, # 10 p. 3910 - 3919]

Solvolysis of K-region arene oxides: substituent effects on reactions of benz [a] anthracene 5, 6-oxide

[Nashed, Nashaat T.; Balani, Suresh K.; Loncharich, Richard J.; Sayer, Jane M.; Shipley, David Y.; Mohan, Ram S.; Whalen, Dale L.; Jerina, Donald M. Journal of the American Chemical Society, 1991 , vol. 113, # 10 p. 3910 - 3919]

More Articles...