The small peptide-catalyzed direct asymmetric aldol reaction in water

P Dziedzic, W Zou, J Háfren, A Córdova

Index: Dziedzic, Pawel; Zou, Weibiao; Hafren, Jonas; Cordova, Armando Organic and Biomolecular Chemistry, 2006 , vol. 4, # 1 p. 38 - 40

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Citation Number: 175

Abstract

Simple modular di-and tripeptides with a primary amine at the N-terminus catalyze the aqueous asymmetric aldol reaction between unmodified ketones and aldehydes to furnish the corresponding β-hydroxy ketones with up to 86% ee in water and 99% ee in aqueos media.