A vHTS approach for the identification of β-adrenoceptor ligands
…, A Ammendola, K Wolf, T Wieber, J Schachtner…
Index: Tasler, Stefan; Baumgartner, Roland; Aschenbrenner, Andrea; Ammendola, Astrid; Wolf, Kristina; Wieber, Tanja; Schachtner, Josef; Blisse, Marcus; Quotschalla, Udo; Ney, Peter Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 11 p. 3399 - 3404
Full Text: HTML
Citation Number: 5
Abstract
Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... Using a vHTS based on a pharmacophore alignment on known β3-adrenoceptor ligands, a set of intriguing β-adrenoceptor ligands was identified, optimization of which resulted in a selective and potent human β2-AR antagonist. ... Templates chosen for a pharmacophore alignment and ...
Related Articles:
Indoloxypropanolamine analogues as 5-HT 1A receptor antagonists
[Krushinski Jr., Joseph H.; Schaus, John M.; Thompson, Dennis C.; Calligaro, David O.; Nelson, David L.; Luecke, Susan H.; Wainscott, David B.; Wong, David T. Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 20 p. 5600 - 5604]