Reductive amination agents: comparison of Na (CN) BH 3 and Si-CBH
PN Grenga, BL Sumbler, F Beland, R Priefer
Index: Grenga, Paolo N.; Sumbler, Brittany L.; Beland, Francois; Priefer, Ronny Tetrahedron Letters, 2009 , vol. 50, # 48 p. 6658 - 6660
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Citation Number: 21
Abstract
Reductive amination is a chemical reaction commonly employed by organic chemists in academics and the pharmaceutical industry. In this reaction a carbonyl group is converted to an amine via an imine intermediate, the formation of which is rate limiting. A major reagent necessary for the completion of this reaction is a hydride source, commonly sodium cyanoborohydride (Na (CN) BH3). The objective of this research was to compare the ...
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