Aryl vinyl sulfonates and sulfones as active site-directed and mechanism-based probes for protein tyrosine phosphatases

…, H Yang, Y He, ZX Jiang, S Kumar, L Wu…

Index: Liu, Sijiu; Zhou, Bo; Yang, Heyi; He, Yantao; Jiang, Zhong-Xing; Kumar, Sanjai; Wu, Li; Zhang, Zhong-Yin Journal of the American Chemical Society, 2008 , vol. 130, # 26 p. 8251 - 8260

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Citation Number: 83

Abstract

Protein tyrosine phosphatases (PTPs) play key roles in the regulation of normal and pathological processes ranging from cell proliferation, differentiation, metabolism, and survival to many human diseases including cancer and diabetes. Functional studies of PTP can be greatly facilitated by small molecule probes that covalently label the active site of a PTP through an activity-dependent chemical reaction. In this article, we characterize ...