Solvent-free condensations of ketones with malononitrile catalysed by methanesulfonic acid/morpholine system

…, K Jamroży, MK Łuczyński, P Brzuzan, M Woźny

Index: Gora; Kozik; Jamrozy; Luczynski; Brzuzan; Wozny Green Chemistry, 2009 , vol. 11, # 6 p. 863 - 867

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Citation Number: 14

Abstract

The preparation of ylidenemalononitriles viaKnoevenagel condensations of ketones with malononitrile under solvent-free conditions is described. Good yields and short reaction time are the features observed with methanesulfonic acid (MSA)/morpholine used as the catalyst. The wide applicability of the protocol is shown by the fact that not only unconjugated, but also aryl-alkyl ketones gave satisfactory yields.