Analytical Chemistry

Chemical derivatization for electrospray ionization mass spectrometry. 1. Alkyl halides, alcohols, phenols, thiols, and amines

JME Quirke, CL Adams, GJ Van Berkel

Index: Quirke, J. Martin E.; Adams, Christopher L.; Van Berkel, Gary J. Analytical Chemistry, 1994 , vol. 66, # 8 p. 1302 - 1315

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Citation Number: 157

Abstract

Derivatization strategies and specific derivatization reactions for conversion of simple alkyl halides, alcohols, phenols, thiols, and amines to ionic or solution-ionizable derivatives, that is “electrospray active”(ES-active) forms of the analyte, are presented. Use of these reactions allows detection of analytes among those listed that are not normally amenable to analysis by electrospray ionization mass spectrometry (ES-MS). In addition, these reactions ...