CLEFMA—An anti-proliferative curcuminoid from structure–activity relationship studies on 3, 5-bis (benzylidene)-4-piperidones

P Lagisetty, P Vilekar, K Sahoo, S Anant…

Index: Lagisetty, Pallavi; Vilekar, Prachi; Sahoo, Kaustuv; Anant, Shrikant; Awasthi, Vibhudutta Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 16 p. 6109 - 6120

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Citation Number: 42

Abstract

3, 5-Bis (benzylidene)-4-piperidones are being advanced as synthetic analogs of curcumin for anti-cancer and anti-inflammatory properties. We performed structure–activity relationship studies, by testing several synthesized 3, 5-bis (benzylidene)-4-piperidones for anti-proliferative activity in lung adenocarcinoma H441 cells. Compared to the lead compound 1, or 3, 5-bis (2-fluorobenzylidene)-4-piperidone, five compounds were found ...