First synthesis of 2, 6-diazabicyclo [3.2. 0] heptane derivatives

C Napolitano, M Borriello, F Cardullo, D Donati…

Index: Napolitano, Carmela; Borriello, Manuela; Cardullo, Francesca; Donati, Daniele; Paio, Alfredo; Manfredini, Stefano Tetrahedron Letters, 2009 , vol. 50, # 52 p. 7280 - 7282

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Citation Number: 4

Abstract

The first synthesis of 6-phenyl-2, 6-diazabicyclo [3.2. 0] heptane 1 and its orthogonally protected precursor 2 is herein reported. Our strategy enables to chemically address the two nitrogen atoms of 2, 6-diazabicyclo [3.2. 0] heptane core individually and selectively, thus allowing rapid access to several subsets of widely substituted fused azetidines.