N. omega.-(2-Mercaptoethyl) derivatives of ornithine and lysine as antiradiation agents

…, AG Laseter, TP Johnston, MM Grenan

Index: Piper; Rose; Laseter; Johnston; Grenan Journal of medicinal chemistry, 1974 , vol. 17, # 10 p. 1119 - 1120

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Citation Number: 4

Abstract

The conversion of diethyl acetamidomalonate (1) to the oxazolidinones 2a, b and the ring opening with hydrogen bromide'to give the bromoethylamine hydrobromides 3a, b were the promising beginnings of the sequence (Scheme I) that eventually led to 6a, b. The initial step is the first example of C-alkylation with 3-(w-chloroalkyl)-2-oxazolidinones and complements the utility of previous examples of 0-, N-, and S-alkylations. 7 The ring-opening step was ...