Synthesis of radiolabeled O6??benzylguanine derivatives as new potential PET tumor imaging agents for the DNA repair protein O6??alkylguanine??DNA …

…, X Liu, X Fei, JQ Wang, DW Ohannesian…

Index: Zheng, Qi-Huang; Liu, Xuan; Fei, Xiangshu; Wang, Ji-Quan; Ohannesian, David W.; Erickson, Leonard C.; Stone, K. Lee; Martinez, Tanya D.; Miller, Kathy D.; Hutchins, Gary D. Journal of Labelled Compounds and Radiopharmaceuticals, 2002 , vol. 45, # 14 p. 1239 - 1252

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Citation Number: 28

Abstract

Abstract Novel radiolabeled O 6-benzylguanine derivatives, 2-amino-6-O-[11 C]- [(methoxymethyl) benzyloxy]-9-benzyl purines ([11 C] pO 6-AMBP, 1a;[11 C] mO 6-AMBP, 1b;[11 C] oO 6-AMBP, 1c), have been synthesized for evaluation as new potential positron emission tomography (PET) tumor imaging agents for the DNA repair protein, O 6- alkylguanine-DNA alkyltransferase (AGT). The appropriate precursors for radiolabeling ...