Subtype-selectivity of metal-dependent methionine aminopeptidase inhibitors

MA Altmeyer, A Marschner, R Schiffmann…

Index: Altmeyer, Markus A.; Marschner, Aline; Schiffmann, Rolf; Klein, Christian D. Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 14 p. 4038 - 4044

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Citation Number: 13

Abstract

Inhibitors of methionine aminopeptidases (MetAPs) are treatment options for various pathological conditions. Several inhibitor classes have been described previously, but only few data on the subtype selectivity, which is of crucial importance for these enzymes, is available. We present a systematic study on the subtype-and species-selectivity of MetAP inhibitors that require the binding of an auxiliary metal ion. This includes, in particular, ...