Synthesis of Symmetrically and Unsymmetrically Substituted. alpha.-Diones from Organometallic Reagents and 1, 4-Dialkylpiperazine-2, 3-diones

UT Mueller-Westerhoff, M Zhou

Index: Mueller-Westerhoff, Ulrich T.; Zhou, Ming Journal of Organic Chemistry, 1994 , vol. 59, # 17 p. 4988 - 4992

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Citation Number: 41

Abstract

We wish to present details about a simple, high-yield, two-step synthesis of symmetrically substituted a-diones' and about how it can be extended to the preparation of unsymmetrically substituted a-diones (Scheme 1). The method is based on the well-known2 synthesis of aldehydes and ketones using dialkylamides and Grignard or organolithium reagents (eq 11, in which the stability