Highly Enantioselective Rh-Catalyzed Hydrogenation of β, γ-Unsaturated Phosphonates with Chiral Ferrocene-Based Monophosphoramidite Ligands
ZC Duan, XP Hu, C Zhang, DY Wang…
Index: Duan, Zheng-Chao; Hu, Xiang-Ping; Zhang, Cheng; Wang, Dao-Yong; Yu, Sai-Bo; Zheng, Zhuo Journal of Organic Chemistry, 2009 , vol. 74, # 23 p. 9191 - 9194
Full Text: HTML
Citation Number: 34
Abstract
An enantioselective synthesis of chiral alkylphosphonates bearing a β-stereogenic center, based on the Rh-catalyzed asymmetric hydrogenation of corresponding β-substituted β, γ- unsaturated phosphonates with a ferrocene-based monophosphoramidite ligand under the mild hydrogenation conditions, was developed, in which an ee value of up to 98% was obtained.
Related Articles:
A Convenient (E)-Stereoselective Synthesis of Alkenylphosphonates
[Truel, Isabelle; Mohamed-Hachi, Abdourahman; About-Jaudet, Elie; Collignon, Noel Synthetic Communications, 1997 , vol. 27, # 2 p. 297 - 302]
A Convenient (E)-Stereoselective Synthesis of Alkenylphosphonates
[Truel, Isabelle; Mohamed-Hachi, Abdourahman; About-Jaudet, Elie; Collignon, Noel Synthetic Communications, 1997 , vol. 27, # 2 p. 297 - 302]
A Convenient (E)-Stereoselective Synthesis of Alkenylphosphonates
[Truel, Isabelle; Mohamed-Hachi, Abdourahman; About-Jaudet, Elie; Collignon, Noel Synthetic Communications, 1997 , vol. 27, # 2 p. 297 - 302]